Postmenopausal bleeding profile

86% of postmenopausal women treated with ACTIVELLA® 1.0 mg/0.5 mg were amenorrheic by the end of study

In a 12-month, prospective, double-blind, parallel-group, multicenter study of 583 postmenopausal women, 290 were randomized to receive ACTIVELLA® 1.0 mg/0.5 mg.

*Cumulative amenorrhea rate represents the percentage of women who were amenorrheic in a given cycle and remained so throughout the trial according to a retrospective analysis. If data were missing, the bleeding value from the last reported day was carried forward (LOCF).

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Important Safety Information

REFERENCES:

  • 1. ACTIVELLA® [package insert]. Princeton, NJ: Novo Nordisk Inc; 2007.
  • 5. Ettinger B, Pressman A, Silver P. Effect of age on reasons for initiation and discontinuation of hormone replacement therapy. Menopause. 1999;6:282-289.
  • 6. Johnson JV, Davidson M, Archer D, Bachmann G. Postmenopausal uterine bleeding profiles with two forms of continuous combined hormone replacement therapy. Menopause. 2002;9:16-22.